The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Ultimate mimicry: methamphetamine-induced pseudovasculitis.
The American journal of medicine 2015 Apr;128;364-6 — 2015 Apr — 364-6
Methamphetamine-related sudden death with a concentration which was of a 'toxic level'.
Legal medicine (Tokyo, Japan) 2006 May;8;150-5 — 2006 May — 150-5
Methamphetamine abuse: a perfect storm of complications.
Mayo Clinic proceedings 2006 Jan;81;77-84 — 2006 Jan — 77-84
Crystal methamphetamine-induced acute pulmonary edema: a case report.
Hawaii medical journal 1989 Nov;48;457-8, 460 — 1989 Nov — 457-8, 460
Acute pulmonary oedema caused by crystalline methamphetamine.
Lancet (London, England) 1989 Nov 25;2;1277-8 — 1989 Nov 25 — 1277-8