The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Clopidogrel-induced Eosinophilia and Hypercalcemia with Multiple Organ Lesions Including Eosinophilic Pneumonia: A Case Report.
Internal medicine (Tokyo, Japan) 2022 Feb 08;; — 2022 Feb 08
Yamada K, Asai K, Yanagimoto M, Sone R, Inazu S, Mizutani R, Kadotani H, Watanabe T, Tochino Y, Kawaguchi T
Clopidogrel-induced Eosinophilia with Hypercalcemia: A Case Report.
Internal medicine (Tokyo, Japan) 2022 Feb 08;; — 2022 Feb 08
Severe clopidogrel-induced DRESS with eosinophilic pneumonia associated with Epstein-Barr virus reactivation.
Respirology case reports 2020 Apr;8;e00541 — 2020 Apr — e00541
[A case of clopidogrel-induced eosinophilic pneumonia].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2011 Nov;49;838-42 — 2011 Nov — 838-42