The Drug-Induced Respiratory Disease Website
(Fr: SDRA sur critères gazométriques PaO2/FIO2). May overlap with Ia. Mechanical ventilation commonly needed. ECMO required in some instances (PMID 29967877). ARDS definition and grading at PMID 22797452. ARDS (and formerly ALI) are defined on the basis of gas exchange abnormalities. Thus, ARDS is not a well-characterized disease entity and may arise in widely disparate clinical scenarios. Pathologically, ARDS may correspond to DAD, pulmonary edema, acute NSIP-like ILD w/wo granulomas, -eosinophilic pneumonia (AEP), AFOP, amiodarone pulmonary toxicity, DAH, fat or silicone embolism, AIP, radiation injury, pulmonary fibrosis exacerbated by drugs or surgery (see under specific patterns) and drug- or alcohol-induced aspiration pneumonitis (see under XIg). Appropriate tests and BAL help exclude an infection and separate these entities. Some patients respond to intravenous corticosteroid therapy. Review at PMID 1939859. See also under IL 'Diffuse Alveolar Damage', XIg, XVf and under 'Postoperative ARDS'
Publications
The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.
JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108
Trimethoprim-sulfamethoxazole-induced lung injury: a case report.
Translational pediatrics 2023 Nov 28;12;2062-2073 — 2023 Nov 28 — 2062-2073
Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment.
Journal of pediatric intensive care 2022 Mar;11;67-71 — 2022 Mar — 67-71
Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y
ARDS With Pneumothorax in a Young Adult.
Chest 2022 Feb;161;e111-e116 — 2022 Feb — e111-e116
Trimethoprim-Sulfamethoxazole Associated Fulminant Respiratory Failure in Children and Young Adults.
American journal of respiratory and critical care medicine 2021 Jan 29;; — 2021 Jan 29
Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole.
Pediatrics 2019 Jun;143; — 2019 Jun
Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.
The American review of respiratory disease 1987 Oct;136;1003-4 — 1987 Oct — 1003-4
Adult respiratory distress syndrome and trimethoprim-sulfamethoxazole.
Annals of internal medicine 1987 Feb;106;331 — 1987 Feb — 331
Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.
Drug intelligence & clinical pharmacy 1988 Jan;22;43-5 — 1988 Jan — 43-5