The Drug-Induced Respiratory Disease Website

Docetaxel

Capillary leak syndrome (CLS)

See also under Xr. Thoracic manifestations may include pulmonary edema, ARDS and pleural effusions (See also under IIa, IIb and Va). Review on causal circumstances and drug at PMID 30404164. Review in french at PMID 25600329

Publications

Amathieu R, Tual L, Fessenmeyer C, Dhonneur G

[Docetaxel-induced acute pulmonary capillary-leak syndrome mimicking cardiogenic oedema].

Annales francaises d'anesthesie et de reanimation 2007 Feb;26;180-1 — 2007 Feb — 180-1

Semb KA, Aamdal S, Oian P

Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998 Oct;16;3426-32 — 1998 Oct — 3426-32

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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