The Drug-Induced Respiratory Disease Website

Marijuana, cannabis (haschish, hash, bang, dab)

Pneumoconiosis (silicosis, talcosis...)

(Fr: pneumoconiose-talcose). Mineral dust-induced lung disease. Mainly due to exposure to drugs (mostly abused) containing silica or talc. Not unlike occupational silicosis, large airway involvement remains a possibility (PMID 18583512)

Publications

McGraw MD, Houser GH, Galambos C, Wartchow EP, Stillwell PC, Weinman JP

Marijuana medusa: The many pulmonary faces of marijuana inhalation in adolescent males.

Pediatric pulmonology 2018 12;53;1619-1626 — 2018 12 — 1619-1626

Scheel AH, Krause D, Haars H, Schmitz I, Junker K

Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report.

Diagnostic pathology 2012 Mar 15;7;26 — 2012 Mar 15 — 26

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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