The Drug-Induced Respiratory Disease Website

Mefloquine

Acute lung injury - ARDS

See also http://www.fda.gov/downloads/drugs/drugsafety/drugsafetynewsletter/ucm109178.pdf

Virzì F, Giacopelli G, Tutone P, Profera L, Giarratano A, Raineri SM, Tomasello S, Accurso G

Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.

Respiratory medicine case reports 2025;56;102238 — 2025 — 102238

Udry E, Bailly F, Dusmet M, Schnyder P, Lemoine R, Fitting JW

Pulmonary toxicity with mefloquine.

The European respiratory journal 2001 Nov;18;890-2 — 2001 Nov — 890-2

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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