The Drug-Induced Respiratory Disease Website

(Fr: dommage alveolaire diffus). Strictly speaking, DAD is a pathologic term denoting alveolar fibrin, hyaline membranes, reactive epithelial cells and varied stages of inflammation (see under 'Pathology'). Of note, hemosiderin-laden macrophages may be found in the BAL in authentic DAD cases (19129275). Nowadays, not many cases undergo a confirmatory lung biopsy. Hence DAD is more often assumed than proved on the basis of respiratory failure and diffuse haze or ground-glass on imaging (Reviews at PMID 19398592 and 20441502). To the clinician, 'clinically consistent DAD' may reflect those cases with diffuse haze, GGO and severe hypoxemia. Here and under XVf we list only those drugs with pathologically-confirmed DAD. Radiographically-diagnosed DAD must be considered as low evidence. Similar list under pathology, XVf