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The Drug-Induced Respiratory Disease Website

Amlodipine

X.b

Pulmonary edema, noncardiogenic (NCPE)

A complication of drug overdose

Publications

Lindeman E, Ålebring J, Johansson A, Ahlner J, Kugelberg FC, Nordmark Grass J

The unknown known: non-cardiogenic pulmonary edema in amlodipine poisoning, a cohort study.

Clinical toxicology (Philadelphia, Pa.) 2020 Mar 02;;1-8 — 2020 Mar 02 — 1-8

Hedaiaty M, Eizadi-Mood N, Sabzghabaee AM

Noncardiogenic Pulmonary Edema after Amlodipine Overdose without Refractory Hypotension and Bradycardia.

Case reports in emergency medicine 2015;2015;546012 — 2015 — 546012

Kute VB, Shah PR, Goplani KR, Gumber MR, Vanikar AV, Trivedi HL

Successful treatment of refractory hypotension, noncardiogenic pulmonary edema and acute kidney injury after an overdose of amlodipine.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2011 Jul;15;182-4 — 2011 Jul — 182-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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