The Drug-Induced Respiratory Disease Website

Azithromycin

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Kränke B, Aberer W

Macrolide-induced Churg-Strauss syndrome in patient with atopy.

Lancet (London, England) 1997 Nov 22;350;1551-2 — 1997 Nov 22 — 1551-2

Hübner C, Dietz A, Stremmel W, Stiehl A, Andrassy H

Macrolide-induced Churg-Strauss syndrome in a patient with atopy.

Lancet (London, England) 1997 Aug 23;350;563 — 1997 Aug 23 — 563

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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