The Drug-Induced Respiratory Disease Website

Benzodiazepines

Hiccup

For review see Bagheri et al. 1999 (PMID: 10216420) and Thompson and Landry 1997 (PMID 9066948)

Martínez Rey C, Villamil Cajoto I

[Hiccup: review of 24 cases].

Revista medica de Chile 2007 Sep;135;1132-8 — 2007 Sep — 1132-8

Micallef J, Tardieu S, Pradel V, Blin O

[Benzodiazepine and hiccup: three case reports].

Therapie 2005 Jan-Feb;60;57-60 — 2005 Jan-Feb — 57-60

Thompson DF, Landry JP

Drug-induced hiccups.

The Annals of pharmacotherapy 1997 Mar;31;367-9 — 1997 Mar — 367-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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