The Drug-Induced Respiratory Disease Website

Lidocaine (lignocaine, xylocaine)

Central airway instability - Tracheomalacia

Nielson DW, Ku PL, Egger M

Topical lidocaine exaggerates laryngomalacia during flexible bronchoscopy.

American journal of respiratory and critical care medicine 2000 Jan;161;147-51 — 2000 Jan — 147-51

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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