Philippe Camus, M.D.

Dijon, France

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XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Hypersensitivity and infusion reactions. May mimic systemic vasculitis (PMID 30746133). See also under 'Anaphylaxis' (Xf). Hypersensitivity reactions include the rapid development of malaise, cough, dyspnea, wheezing-bronchospasm, cutaneous rash, itching and pruritus. These symptoms may annunciate the onset of anaphylaxis (see Xf) especially if the drug is continued or the patient is inadvertenly rechallenged with the drug. Desensitization can be offered (PMID 26895621), so that patients can receive full treatment courses and need not be switched to an alternative, potentially more toxic or inferior therapy. See PMID 12634903, 12721396, 22149339, 22987983. Skin manifestations at PMID 24820798

Publications

Chang YS

Hypersensitivity reactions to proton pump inhibitors.

Current opinion in allergy and clinical immunology 2012 Aug;12;348-53 — 2012 Aug — 348-53

Bergmann M, Guignard B, Ribi C

[Hypersensitivity to proton pump inhibitors].

Revue medicale suisse 2012 Apr 18;8;830-5 — 2012 Apr 18 — 830-5