The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Betaxolol-induced deterioration of asthma and a pharmacodynamic analysis based on beta-receptor occupancy.
International journal of clinical pharmacology and therapeutics 2003 Aug;41;358-64 — 2003 Aug — 358-64
The effect of topical ophthalmic instillation of timolol and betaxolol on lung function in asthmatic subjects.
The American review of respiratory disease 1986 Feb;133;264-8 — 1986 Feb — 264-8
Respiratory tolerance of bisoprolol and metoprolol in asthmatic patients.
Journal of cardiovascular pharmacology 1986;8 Suppl 11;S69-73 — 1986 — S69-73