The Drug-Induced Respiratory Disease Website
DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome
Evidence level
possible
DRESS stands for 'Drug Rash, Eosinophilia, Systemic Symptoms or Syndrome'. Includes internal organ involvement (liver, bone marrow, kindney, lung, heart in the form of myocarditis (PMID 21658796)) and occasionally MOF/MODS. Respiratory involvement (in about 15% of the patients), is in the form of cough, dyspnea, wheezing, pleural effusion, pulmonary infiltrates or PIE. See also under eosinophilic pneumonia. A precise definition of the syndrome has been available since 1996 (Bocquet et al.). Earlier cases of 'Drug Hypersensitivity' in the literature likely represent authentic DRESS cases. Review and lists of causal drugs at PMID 21592453, 26354734. Reviews at PMID 23602182, 23602183, 25592341, 30140942. Pulmonary manifestations at PMID 31662996. Causal drugs at PMID 32247873 and 35160164.
the heart in DRESS @ PMID 35160164.
Publications
DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result.
Rheumatology international 2012 Jul;32;2181-4 — 2012 Jul — 2181-4
[Cross-hypersensitivity syndrome between antiepileptic drugs: report of a case].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2004 Jan-Feb;28;56-8 — 2004 Jan-Feb — 56-8