The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
[Is celecoxib a safe alternative for the Fernand Widal syndrome?].
Revue des maladies respiratoires 2018 Feb;35;149-159 — 2018 Feb — 149-159
Kim YJ, Lim KH, Kim MY, Jo EJ, Lee SY, Lee SE, Yang MS, Song WJ, Kang HR, Park HW, Chang YS, Cho SH, Min KU, Kim SH
Cross-reactivity to Acetaminophen and Celecoxib According to the Type of Nonsteroidal Anti-inflammatory Drug Hypersensitivity.
Allergy, asthma & immunology research 2014 Mar;6;156-62 — 2014 Mar — 156-62
Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?
Allergologia et immunopathologia 2013;41;181-8 — 2013 — 181-8
Umemoto J, Tsurikisawa N, Nogi S, Iwata K, Oshikata C, Tatsuno S, Tanimoto H, Sekiya K, Tsuburai T, Mitomi H, Akiyama K
Selective cyclooxygenase-2 inhibitor cross-reactivity in aspirin-exacerbated respiratory disease.
Allergy and asthma proceedings 2011 May-Jun;32;259-61 — 2011 May-Jun — 259-61
Asthma attacks induced by low doses of celecoxib, aspirin, and acetaminophen.
The Journal of allergy and clinical immunology 2006 Jan;117;215-7 — 2006 Jan — 215-7