Philippe Camus, M.D.

Dijon, France

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XXVIII.a

Angioedema (may cause UAO, asphyxia and death)

See PMID 30075570. Review at PMID 28291095. Major risk is UAO, with consequent asphyxia. Can be followed by irreversible hypoxic brain damage/death. See also under VIIIg. May occur in isolation or accompany drug-induced anaphylaxis. Airway angioedema can be in the form of acute swelling of the lips, tongue, mouth floor, uvula, pharynx, larynx, glottis, subglottic area and/or upper trachea. This can cause acute upper airway obstruction (UAO) and asphyxia. May overlap with IVb. Expedient identification the airway by endoscopy and maintenance of airway patency are crucially important, as if the UAO progresses emergent risky tracheostomy can be required. Icatibant may alleviate all manifestations of drug-induced angioedema (PMID: 22936825). Rebound phenomenon can occur after an initial falsely reassuring period of improvement. NPPE (IIg) may occur as a secondary complication. Reviews and series at PMID 20447725, 20667117, 20922352, 22552531, 22936825, 22976464, 25059449. Angioedema can also involve the bowel wall in concomitance, causing abdominal pain or cramping or simulate an acute abdomen (PMID: 20376210, 21785085, 22867837)

 

Publications

Landry L, Witten T, Anwar AI, Jackson CN, Talbot NC, Ahmadzadeh S, Varrassi G, Shekoohi S, Kaye AD

Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema.

Cureus 2023 Nov;15;e49306 — 2023 Nov — e49306

Day C, Van der Walt J, Crombie K, Hendrikse C, Peter J

Acute angioedema in Cape Town emergency centres and a suggested algorithm to simplify and improve management.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2023 Aug 03;113;51-57 — 2023 Aug 03 — 51-57

Depetri F, Tedeschi A, Cugno M

Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment.

European journal of internal medicine 2019 01;59;8-13 — 2019 01 — 8-13

Felder S, Curtis RM, Ball I, Borici-Mazi R

Prognostic factors in outcome of angioedema in the emergency department.

Allergy and asthma proceedings 2014 Sep-Oct;35;362-70 — 2014 Sep-Oct — 362-70

Bertazzoni G, Spina MT, Scarpellini MG, Buccelletti F, De Simone M, Gregori M, Valeriano V, Pugliese FR, Ruggieri MP, Magnanti M, Susi B, Minetola L, Zulli L, D'Ambrogio F

Drug-induced angioedema: experience of Italian emergency departments.

Internal and emergency medicine 2014 Jun;9;455-62 — 2014 Jun — 455-62

Cimbollek S, Ortega Camarero M, Avila R, Quiralte J, Prados M

NSAID-sensitive antihistamine-induced urticaria/angioedema.

Journal of investigational allergology & clinical immunology 2011;21;488-90 — 2011 — 488-90

Downing A, Jacobsen J, Sorensen HT, McLaughlin JK, Johnsen SP

Risk of hospitalization for angio-oedema among users of newer COX-2 selective inhibitors and other nonsteroidal anti-inflammatory drugs.

British journal of clinical pharmacology 2006 Oct;62;496-501 — 2006 Oct — 496-501

Sánchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A

Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2005 Aug;95;154-8 — 2005 Aug — 154-8

Gabb GM, Ryan P, Wing LM, Hutchinson KA

Epidemiological study of angioedema and ACE inhibitors.

Australian and New Zealand journal of medicine 1996 Dec;26;777-82 — 1996 Dec — 777-82

Figueras A, Capellà D, Castel JM, Laorte JR

Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.

European journal of clinical pharmacology 1994;47;297-303 — 1994 — 297-303