The Drug-Induced Respiratory Disease Website

Chloroquine

Cardiomyopathy (acute, subacute, chronic)

Review on PMID 29858838

Chatre C, Roubille F, Vernhet H, Jorgensen C, Pers YM

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.

Drug safety 2018 10;41;919-931 — 2018 10 — 919-931

Saussine A, Loriot MA, Picard C, Lecerf V, Landry J, Scheer I, Voicu S, Leenhardt A, Ducrocq G, Maubec E, Crickx B

[Chloroquine cardiotoxicity in long-term lupus therapy in two patients].

Annales de dermatologie et de venereologie 2009 Jun-Jul;136;530-5 — 2009 Jun-Jul — 530-5

Veinot JP, Mai KT, Zarychanski R

Chloroquine related cardiac toxicity.

The Journal of rheumatology 1998 Jun;25;1221-5 — 1998 Jun — 1221-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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