The Drug-Induced Respiratory Disease Website

Myocardial stunning

Angelini P

Re: Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning.

Nature clinical practice. Cardiovascular medicine 2008 Jun;5;E1; author reply E2 — 2008 Jun — E1; author reply E2

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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