The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.
JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108
Mochizuka Y, Fujisawa T, Inoue Y, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T
Trimethoprim-sulfamethoxazole induced eosinophilic pneumonia: A case report.
Respiratory medicine case reports 2022;37;101632 — 2022 — 101632
Sulfa-induced acute eosinophilic pneumonia.
Respiratory medicine case reports 2021;34;101496 — 2021 — 101496
[Drug induced interstitial lung diseases after treatment with cotrimoxazole. 2 cases].
La Nouvelle presse medicale 1980 Sep 20;9;2347 — 1980 Sep 20 — 2347
Hypersensitivity pneumonitis induced by trimethoprim.
BMJ (Clinical research ed.) 1990 May 19;300;1344 — 1990 May 19 — 1344