The Drug-Induced Respiratory Disease Website

Dasatinib

Fluid retention

May manifest with weight gain, tissue edema, cardiomegaly and electrlyte disturbances. See also under Xc

Masiello D, Gorospe G, Yang AS

The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib.

Journal of hematology & oncology 2009 Nov 12;2;46 — 2009 Nov 12 — 46

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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