The Drug-Induced Respiratory Disease Website

Arsenic trioxide (As2O3)

Fluid retention

May manifest with weight gain, tissue edema, cardiomegaly and electrlyte disturbances. See also under Xc

Arai A, Kitano A, Kurosu T, Yamamoto K, Miki T, Murakami N, Miura O

Fluid retention during arsenic trioxide treatment in acute promyelocytic leukemia.

American journal of hematology 2005 Jul;79;247-8 — 2005 Jul — 247-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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