The Drug-Induced Respiratory Disease Website
Corresponds to circulating autoantibodies (ANA, anti-dsDNA, multispecific ANCA). Titers can be very high and/or multispecific and tend to diminish in a few weeks or months upon drug discontinuance. Autoimmunity can be asymptomatic or is with various clinical presentations including pulmonary vascultis or hemorrhage (PMID 20015613). See also under patterns IIIa, IIIb, IIId, Vd, VId, and Xb, d, h, j, m, s, x, y, ac, ah, am, ao, aw, ax, ay
Publications
Overlapping drug-induced vasculitis, ANCA-associated vasculitis, and lupus nephritis caused by low-dose hydralazine.
International journal of rheumatic diseases 2023 Jul 14;; — 2023 Jul 14
Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.
Cureus 2021 Oct;13;e18974 — 2021 Oct — e18974
Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.
Journal of medical case reports 2020 Apr 15;14;47 — 2020 Apr 15 — 47
Clinical Characteristics of Hydralazine-induced Lupus.
Cureus 2019 Jun 25;11;e4996 — 2019 Jun 25 — e4996
An intriguing case of anemia and renal failure.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;78-79 — 2019 Jan — 78-79
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019 Jan-Feb;30;226-230 — 2019 Jan-Feb — 226-230
Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.
Modern rheumatology 2009;19;338-47 — 2009 — 338-47
Rheumatoid arthritis-like syndrome during apresoline therapy: report of a case.
The Medical annals of the District of Columbia 1953 Dec;22;651-2 — 1953 Dec — 651-2