The Drug-Induced Respiratory Disease Website
Drug-induced ANCA-associated or related systemic disease (formerly known as Wegener's) may manifest with vasculitis in almost any organ, arthritis, skin, kidney, lung (usually in the form of DAH) or other end-organ involvement mimicking idiopathic ANCA-related granulomatosis and polyangiitis (Wegener) or PAN. ANCA titers can be very high and multispecific, decreasing upon drug discontinuance paralleling clinical improvement. Treatment approach in severe cases is similar to primary ANCA disease. See under IIId, VId, Xm and at PMID 21674413. ANCA specificity for cocaine and levamisole at PMID 21654271. Early cases at a time ANCA were not described may be found under Xm. Reviews at PMID 19335842, 24485158
Publications
Diagnostic dilemma: drug-induced vasculitis versus systemic vasculitis.
BMJ case reports 2023 Jul 10;16; — 2023 Jul 10
The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.
Case reports in pulmonology 2023;2023;1461011 — 2023 — 1461011
Rare complication of a commonly used antihypertensive agent: A case of hydralazine-induced ANCA-associated vasculitis presenting as rapidly progressive glomerulonephritis.
Clinical case reports 2022 Feb;10;e05411 — 2022 Feb — e05411
Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.
Cureus 2021 Oct;13;e18974 — 2021 Oct — e18974
Antineutrophil cytoplasmic antibody vasculitis induced by hydralazine.
Cutis 2020 Jan;105;E32-E35 — 2020 Jan — E32-E35
An intriguing case of anemia and renal failure.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;78-79 — 2019 Jan — 78-79
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019 Jan-Feb;30;226-230 — 2019 Jan-Feb — 226-230
Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia 2018 Apr-Jun;40;193-197 — 2018 Apr-Jun — 193-197
Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses.
Journal of community hospital internal medicine perspectives 2016;6;30632 — 2016 — 30632
Hydralazine induces myeloperoxidase and proteinase 3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary renal syndrome.
Case reports in nephrology 2014;2014;868590 — 2014 — 868590
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 — 2014 Jan — 42-9
Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report.
Journal of medical case reports 2013 Jan 14;7;20 — 2013 Jan 14 — 20
Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation.
International urology and nephrology 2012 Dec;44;1907-9 — 2012 Dec — 1907-9
Hydralazine-induced ANCA-positive pauci-immune glomerulonephritis: a case report and literature review.
Renal failure 2009;31;745-8 — 2009 — 745-8
Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe.
International urology and nephrology 2010 Jun;42;503-6 — 2010 Jun — 503-6
Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.
Modern rheumatology 2009;19;338-47 — 2009 — 338-47
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
Arthritis and rheumatism 2000 Feb;43;405-13 — 2000 Feb — 405-13
Antigen specificity in hydralazine associated ANCA positive systemic vasculitis.
QJM : monthly journal of the Association of Physicians 1995 Nov;88;775-83 — 1995 Nov — 775-83