The Drug-Induced Respiratory Disease Website

Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

Drug-induced ANCA-associated or related systemic disease (formerly known as Wegener's) may manifest with vasculitis in almost any organ, arthritis, skin, kidney, lung (usually in the form of DAH) or other end-organ involvement mimicking idiopathic ANCA-related granulomatosis and polyangiitis (Wegener) or PAN. ANCA titers can be very high and multispecific, decreasing upon drug discontinuance paralleling clinical improvement. Treatment approach in severe cases is similar to primary ANCA disease. See under IIId, VId, Xm and at PMID 21674413. ANCA specificity for cocaine and levamisole at PMID 21654271. Early cases at a time ANCA were not described may be found under Xm. Reviews at PMID 19335842, 24485158

Publications

Karageorgiou I, Pokharel A, Pokharel A, Niedzialkowska E, Bateman J

Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting with Multiple Sterile Abscesses, Mononeuritis Multiplex, and Splenic Vein Thrombosis: A Case Report and Literature Review.

Cureus 2024 May;16;e61229 — 2024 May — e61229

Okuda S, Hirooka Y, Sugiyama M

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after COVID-19 Vaccination.

Vaccines 2021 Jul 31;9; — 2021 Jul 31

Lam B, Yuile A, Fernando SL

Propylthiouracil-induced vasculitis in carbimazole-refractory Graves disease.

The Medical journal of Australia 2019 06;210;491-491.e1 — 2019 06 — 491-491.e1

Hasegawa A, Fujimoto A, Yuki D, Hayashi R, Aizawa A, Ito T, Abe R

PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.

European journal of dermatology : EJD 2018 Aug 01;28;530-531 — 2018 Aug 01 — 530-531

Khan TA, Yin Luk FC, Uqdah HT, Arif A, Hussain H, Jayatilleke A, Aggarwal S

A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis.

Clinical nephrology 2015 May;83;309-14 — 2015 May — 309-14

Iyoda M, Kuroki A, Kato K, Shibata T, Kitazawa K, Sugisaki T

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in a patient with a predisposition to autoimmune abnormalities.

Modern rheumatology 2003 Jun;13;173-6 — 2003 Jun — 173-6

Pendergraft WF, Niles JL

Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.

Current opinion in rheumatology 2014 Jan;26;42-9 — 2014 Jan — 42-9

Wang C, Gou SJ, Xu PC, Zhao MH, Chen M

Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.

Arthritis research & therapy 2013;15;R196 — 2013 — R196

Ozkok A, Kaya S, Elcioglu OC, Odabas AR

Propylthiouracil-induced cryoglobulinemic vasculitis.

Internal medicine (Tokyo, Japan) 2013;52;2011-2 — 2013 — 2011-2

Cao X, Lin W

Clinical study of renal impairment in patients with propylthiouracil-induced small-vessel vasculitis and patients with primary ANCA-associated small-vessel vasculitis.

Experimental and therapeutic medicine 2013 Jun;5;1619-1622 — 2013 Jun — 1619-1622

Rosen DR, Cologne KG, Popek SM, Sung BC, Ortega AE, Senagore AJ

Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.

The American surgeon 2012 Dec;78;1406-8 — 2012 Dec — 1406-8

Tetikkurt C, Yuruyen M, Tetikkurt S, Bayar N, Ozdemir I

Propylthiouracil-induced lupus-like or vasculitis syndrome.

Multidisciplinary respiratory medicine 2012 Jul 17;7;14 — 2012 Jul 17 — 14

Ahmed K, Rao S, Simha V

Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2010 May-Jun;16;449-51 — 2010 May-Jun — 449-51

Sangala N, Lee RW, Horsfield C, Goldsmith DJ

Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe.

International urology and nephrology 2010 Jun;42;503-6 — 2010 Jun — 503-6

Pillinger MH, Staud R

Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue.

Seminars in arthritis and rheumatism 2006 Aug;36;1-3 — 2006 Aug — 1-3

Hardy OT, Smolinski KN, Yan AC, Grimberg A

PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.

Pediatric emergency care 2006 Jan;22;52-4 — 2006 Jan — 52-4

Herlin T, Birkebaek NH, Wolthers OD, Heegaard NH, Wiik A

Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.

Scandinavian journal of rheumatology 2002;31;46-9 — 2002 — 46-9

Choi HK, Merkel PA, Walker AM, Niles JL

Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.

Arthritis and rheumatism 2000 Feb;43;405-13 — 2000 Feb — 405-13

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest 1999 Nov;116;1485-8 — 1999 Nov — 1485-8

Choi HK, Merkel PA, Tervaert JW, Black RM, McCluskey RT, Niles JL

Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.

Arthritis and rheumatism 1999 Feb;42;384-8 — 1999 Feb — 384-8

D'Cruz D, Chesser AM, Lightowler C, Comer M, Hurst MJ, Baker LR, Raine AE

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment.

British journal of rheumatology 1995 Nov;34;1090-1 — 1995 Nov — 1090-1

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