The Drug-Induced Respiratory Disease Website

Hydralazine

Constrictive pericarditis - Pericardial thickening

Franssen CF, el Gamal MI, Gans RO, Hoorntje SJ

Hydralazine-induced constrictive pericarditis.

The Netherlands journal of medicine 1996 May;48;193-7 — 1996 May — 193-7

Richards FM, Fulkerson WJ

Constrictive pericarditis due to hydralazine-induced lupus erythematosus.

The American journal of medicine 1990 Jan;88;56N-59N — 1990 Jan — 56N-59N

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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