The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Disordered breathing pattern - Cheynes-Stokes respiration

Generally occurring during sleep. See also under IXb, IXu, IXq

Cicolin A, Mangiardi L, Mutani R, Bucca C

Angiotensin-converting enzyme inhibitors and obstructive sleep apnea.

Mayo Clinic proceedings 2006 Jan;81;53-5 — 2006 Jan — 53-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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