Back to drug

The Drug-Induced Respiratory Disease Website

(Fr: PnP avec granulomes). 2018 review at PMID 29698718. Characteristically nonnecrotizing, noninfectious, sterile granulomas. Although this is a pathologic pattern, the condition is suspected on a miliary appearance on imaging. Hilar/mediastinal lymphadenopathy can be present. May mimic pulmonary and/or systemic sarcoidosis. Concomittant skin lesions may show granulomas. A confirmarptory lung biopsy may be required (See under Pathology XIV). Careful exclusion of mycobacterial, fungal and Pneumocystis infection is crucial (See PMID 10678649, 18054121, 17257125).

Publications

Hutton Klein JR, Tazelaar HD, Leslie KO, Colby TV

One hundred consecutive granulomas in a pulmonary pathology consultation practice.

The American journal of surgical pathology 2010 Oct;34;1456-64 — 2010 Oct — 1456-64