The Drug-Induced Respiratory Disease Website

Methadone

Disordered breathing pattern - Cheynes-Stokes respiration

Generally occurring during sleep. See also under IXb, IXu, IXq

Webster LR, Choi Y, Desai H, Webster L, Grant BJ

Sleep-disordered breathing and chronic opioid therapy.

Pain medicine (Malden, Mass.) 2008 May-Jun;9;425-32 — 2008 May-Jun — 425-32

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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