The Drug-Induced Respiratory Disease Website

Beta-blockers

Death following exposure or poisoning

From acute asthma attack or from cardias disturbances in poisoning

Spitz DJ

An unusual death in an asthmatic patient.

The American journal of forensic medicine and pathology 2003 Sep;24;271-2 — 2003 Sep — 271-2

Benatar SR, Opie LH

Sudden death in asthmatics receiving beta-blockers.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1982 Aug 28;62;308-9 — 1982 Aug 28 — 308-9

Auzépy P, Boukara N, Richard C, Giudicelli JF

[Acute poisoning caused by beta blockers in the adult. Apropos of 7 cases].

Annales de cardiologie et d'angeiologie 1983 Jun;32;253-8 — 1983 Jun — 253-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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