The Drug-Induced Respiratory Disease Website
Can be acute or subacute in onset. Severity is from the asymptomatic/subclinical state to overt heart failure. May cause acute or chronic left ventricular dysfunction, congestive heart failure (XIIIa) or cardiogenic pulmonary edema (IId). In some cases, will improve with drug stoppage
Publications
Toro-Salazar OH, Gillan E, O'Loughlin MT, Burke GS, Ferranti J, Stainsby J, Liang B, Mazur W, Raman SV, Hor KN
Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy.
Circulation. Cardiovascular imaging 2013 Nov;6;873-80 — 2013 Nov — 873-80
Anthracyclines and heart failure.
The New England journal of medicine 2013 Mar 21;368;1154-6 — 2013 Mar 21 — 1154-6
Acute doxorubicin cardiotoxicity.
The New England journal of medicine 2005 Jun 09;352;2456-7 — 2005 Jun 09 — 2456-7
Early changes in human myocardial nuclei after doxorubicin.
Cancer 1983 Jul 15;52;215-21 — 1983 Jul 15 — 215-21
The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure. Endomyocardial biopsies in 100 consecutive patients revealed a substantial incidence of myocarditis.
Circulation 1984 Jan;69;93-101 — 1984 Jan — 93-101
Hortobagyi GN, Frye D, Buzdar AU, Ewer MS, Fraschini G, Hug V, Ames F, Montague E, Carrasco CH, Mackay B
Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma.
Cancer 1989 Jan 01;63;37-45 — 1989 Jan 01 — 37-45
Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyocardial biopsy, and cardiac catheterization.
Annals of internal medicine 1978 Feb;88;168-75 — 1978 Feb — 168-75
Risk factors for doxorubicin-induced congestive heart failure.
Annals of internal medicine 1979 Nov;91;710-7 — 1979 Nov — 710-7