The Drug-Induced Respiratory Disease Website

Baclofen

Laryngospasm (a.k.a. laryngismus)

Following baclofen withdrawal

Santiago-Palma J, Hord ED, Vallejo R, Trella J, Ahmed SU

Respiratory distress after intrathecal baclofen withdrawal.

Anesthesia and analgesia 2004 Jul;99;227-9 — 2004 Jul — 227-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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