The Drug-Induced Respiratory Disease Website
See PMID 30075570. Review at PMID 28291095. Major risk is UAO, with consequent asphyxia. Can be followed by irreversible hypoxic brain damage/death. See also under VIIIg. May occur in isolation or accompany drug-induced anaphylaxis. Airway angioedema can be in the form of acute swelling of the lips, tongue, mouth floor, uvula, pharynx, larynx, glottis, subglottic area and/or upper trachea. This can cause acute upper airway obstruction (UAO) and asphyxia. May overlap with IVb. Expedient identification the airway by endoscopy and maintenance of airway patency are crucially important, as if the UAO progresses emergent risky tracheostomy can be required. Icatibant may alleviate all manifestations of drug-induced angioedema (PMID: 22936825). Rebound phenomenon can occur after an initial falsely reassuring period of improvement. NPPE (IIg) may occur as a secondary complication. Reviews and series at PMID 20447725, 20667117, 20922352, 22552531, 22936825, 22976464, 25059449. Angioedema can also involve the bowel wall in concomitance, causing abdominal pain or cramping or simulate an acute abdomen (PMID: 20376210, 21785085, 22867837)
Publications
Isolated periorbital angio-oedema induced by aspirin: a case report and review of the literature.
Dental update 2007 Jun;34;302-4 — 2007 Jun — 302-4
Angioedema associated with aspirin and rofecoxib.
The Annals of pharmacotherapy 2005 May;39;944-8 — 2005 May — 944-8
Angioedema and acute asthma attack due to the unexpected occurrence of aspirin in an over-the-counter cold preparation.
The British journal of clinical practice 1996 Oct-Nov;50;412-3 — 1996 Oct-Nov — 412-3
Angioedema and IgE antibodies to aspirin: a case report.
Annals of allergy 1989 Apr;62;295-8 — 1989 Apr — 295-8