The Drug-Induced Respiratory Disease Website
Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
Evidence level
low
Lone, isolated, free-flowing pleural effusion on imaging. See other forms of pleural effusions under Vb, d, e, g, h, i, m which may present similarly on imaging. The effusion can be uni- or bilateral. More often a lymphocyte-, mixed or neutrophil-rich exudate. At times the effusion is eosipophil-rich. Pleural effusion can be present with the acute clinical phase of severe drug-induced ILD (e.g. methotrexate lung; PMID 16840219). In general, pleural effusion in the context of drug-induced ILD or pulmonary edema is not tabulated under this heading. ANA-panel indicated to diagnose drug-induced lupus PMID 10424528
Publications
The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.
Journal of occupational medicine and toxicology (London, England) 2006 Jun 06;1;9 — 2006 Jun 06 — 9
The sulfone syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris.
Journal of pediatric gastroenterology and nutrition 1998 Jan;26;103-5 — 1998 Jan — 103-5
Non-cardiogenic pulmonary oedema associated with pyrimethamine.
Respiratory medicine 1989 May;83;247-8 — 1989 May — 247-8