The Drug-Induced Respiratory Disease Website

Capecitabine

Coronary artery disease (acute) - Myocardial ischemia/infarction

Including acute coronary artery disease or spasm and acute ST segment elevation on ECG/EKG. See also under Xg, XIIo and XIIaf

Henry D, Rudzik F, Butts A, Mathew A

Capecitabine-Induced Coronary Vasospasm.

Case reports in oncology 2016 Sep-Dec;9;629-632 — 2016 Sep-Dec — 629-632

Güvenç TS, Celiker E, Ozcan KS, Ilhan E, Eren M

Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.

Chinese medical journal 2012 Sep;125;3349-51 — 2012 Sep — 3349-51

Ambrosy AP, Kunz PL, Fisher GA, Witteles RM

Capecitabine-induced chest pain relieved by diltiazem.

The American journal of cardiology 2012 Dec 01;110;1623-6 — 2012 Dec 01 — 1623-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.