Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXXVI.m

DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

DRESS stands for 'Drug Rash, Eosinophilia, Systemic Symptoms or Syndrome'. Includes internal organ involvement (liver, bone marrow, kindney, lung, heart in the form of myocarditis (PMID 21658796)) and occasionally MOF/MODS. Respiratory involvement (in about 15% of the patients), is in the form of cough, dyspnea, wheezing, pleural effusion, pulmonary infiltrates or PIE. See also under eosinophilic pneumonia. A precise definition of the syndrome has been available since 1996 (Bocquet et al.). Earlier cases of 'Drug Hypersensitivity' in the literature likely represent authentic DRESS cases. Review and lists of causal drugs at PMID 21592453, 26354734. Reviews at PMID 23602182, 23602183, 25592341, 30140942. Pulmonary manifestations at PMID 31662996. Causal drugs at PMID 32247873 and 35160164.

the heart in DRESS @ PMID 35160164.

Publications

Kinehara Y, Kijima T, Inoue K, Hirata H, Takeuchi Y, Fukushima K, Hayama Y, Higashiguchi M, Morimura O, Miyake K, Minami T, Nagatomo I, Takeda Y, Kida H, Kumanogoh A

Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid.

Internal medicine (Tokyo, Japan) 2015;54;827-31 — 2015 — 827-31

Choi SY, Hwang HY, Lee JH, Park JS, Jang MS

Severe dapsone hypersensitivity syndrome in a child.

Korean journal of pediatrics 2013 Jun;56;260-4 — 2013 Jun — 260-4

Tian W, Shen J, Zhou M, Yan L, Zhang G

Dapsone hypersensitivity syndrome among leprosy patients in China.

Leprosy review 2012 Dec;83;370-7 — 2012 Dec — 370-7

Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS, Kim MB

Dapsone Hypersensitivity Syndrome That Occurred during Treatment of Pediatric Patient with Erythema Elevatum Diutinum.

Annals of dermatology 2011 Dec;23;S290-5 — 2011 Dec — S290-5

Chen YC, Chiu HC, Chu CY

Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases.

Archives of dermatology 2010 Dec;146;1373-9 — 2010 Dec — 1373-9

Derungs A, Rätz Bravo AE, Kummer O

[Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms)].

Praxis 2010 Jun 23;99;767-77; quiz 776 — 2010 Jun 23 — 767-77; quiz 776

Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G

The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.

Journal of occupational medicine and toxicology (London, England) 2006 Jun 06;1;9 — 2006 Jun 06 — 9