The Drug-Induced Respiratory Disease Website

Pentazocine

Crystal pulmonary embolism

See also under VIg, VIh, and under 'Pathology'

Tomashefski JF, Hirsch CS, Jolly PN

Microcrystalline cellulose pulmonary embolism and granulomatosis. A complication of illicit intravenous injections of pentazocine tablets.

Archives of pathology & laboratory medicine 1981 Feb;105;89-93 — 1981 Feb — 89-93

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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