The Drug-Induced Respiratory Disease Website

Pentazocine

Pulmonary arterial hypertension

May reverse with drug discontinuation. Generally similar to primary PHTn clinically, hemodynamically and on pathology. PMID 23997051. A few cases are thromboembolic in nature (PMID 24881082). Reviews at PMID 29508628, 30545968

Publications

Houck RJ, Bailey GL, Daroca PJ, Brazda F, Johnson FB, Klein RC

Pentazocine abuse. Report of a case with pulmonary arterial cellulose granulomas and pulmonary hypertension.

Chest 1980 Feb;77;227-30 — 1980 Feb — 227-30

Farber HW, Falls R, Glauser FL

Transient pulmonary hypertension from the intravenous injection of crushed, suspended pentazocine tablets.

Chest 1981 Aug;80;178-82 — 1981 Aug — 178-82

Lundquest DE, Young WK, Edland JF

Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.

Journal of forensic sciences 1987 May;32;798-801 — 1987 May — 798-801

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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