The Drug-Induced Respiratory Disease Website

Phenazopyridine

Sulfhemoglobinemia

Known from the 1940s (PMID 18883450)

Moritz BW, Chouairi F, Tosh A, Toffaletti JG, Rackley CR

A 36-Year-Old Woman With Intermittent Cyanosis.

Chest 2024 Aug;166;e29-e33 — 2024 Aug — e29-e33

Soderstrom M, Foster DV, Hamidi ZS, Anderson JT

Sulfhemoglobinemia in a 53-Year-Old With a History of Phenazopyridine Misuse.

Cureus 2023 Jun;15;e40944 — 2023 Jun — e40944

Kermani TA, Pislaru SV, Osborn TG

Acrocyanosis from phenazopyridine-induced sulfhemoglobinemia mistaken for Raynaud phenomenon.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2009 Apr;15;127-9 — 2009 Apr — 127-9

Gopalachar AS, Bowie VL, Bharadwaj P

Phenazopyridine-induced sulfhemoglobinemia.

The Annals of pharmacotherapy 2005 Jun;39;1128-30 — 2005 Jun — 1128-30

Halvorsen SM, Dull WL

Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge.

The American journal of medicine 1991 Sep;91;315-7 — 1991 Sep — 315-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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