The Drug-Induced Respiratory Disease Website

Streptokinase

Hemomediastinum - Mediastinal hematoma

Ahmed J, Philpott J, Lew-Gor S, Blunt D

Airway obstruction: a rare complication of thrombolytic therapy.

The Journal of laryngology and otology 2005 Oct;119;819-21 — 2005 Oct — 819-21

Henscher L, Haffner G

[Mediastinal hemorrhage complicating combined streptokinase-anticoagulant therapy (author's transl)].

Rontgen-Blatter; Zeitschrift fur Rontgen-Technik und medizinisch-wissenschaftliche Photographie 1975 Aug;28;380-4 — 1975 Aug — 380-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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