Philippe Camus, M.D.

Dijon, France

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XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

(Fr: PINS aiguë). Acute, generally bilateral and diffuse pneumonitis. More rapid in onset and/or denser, more extensive and severe than pattern Ib. Can be fulminate in the form of diffuse pulmonary interstitial or alveolar opacities and the ARDS picture (see under IIb). BAL is generally lymphocytic and is also indicated to rule out pneumonia due to Pneumocystis, BCG, viruses or other agents particularly in the immunodepressed. Pathology (lung biopsy is not necessary in the majority; before going for the biopsy, please look at PMID 25950989) may disclose dense NSIP, widespread granulomas, or OP depending both on patient and drug. In severe cases pulmonary edema, DAD and/or DAH may develop. Corticosteroid therapy is indicated if patients progress to acute respiratory failure, once an infection has been carefully and resonably ruled out. Transition to pulmonary fibrosis is very uncommon. The boundary between patterns Ia and Ib may be difficult to delineate. See also under IIb

Publications

Powell NR, Shugg T, Ly RC, Albany C, Radovich M, Schneider BP, Skaar TC

Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report.

Frontiers in oncology 2021;11;809527 — 2021 — 809527

Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E

Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.

Respirology case reports 2021 Jul;9;e00802 — 2021 Jul — e00802

Gurram MK, Pulivarthi S, McGary CT

Fatal hypersensitivity pneumonitis associated with docetaxel.

Tumori 2013 May-Jun;99;e100-3 — 2013 May-Jun — e100-3

Karacan O, Eyüboglu FO, Akçay S, Ozyilkan O

Acute interstitial pneumopathy associated with docetaxel hypersensitivity.

Onkologie 2004 Dec;27;563-5 — 2004 Dec — 563-5

Read WL, Mortimer JE, Picus J

Severe interstitial pneumonitis associated with docetaxel administration.

Cancer 2002 Feb 01;94;847-53 — 2002 Feb 01 — 847-53

Wang GS, Yang KY, Perng RP

Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere).

British journal of cancer 2001 Nov 02;85;1247-50 — 2001 Nov 02 — 1247-50

Etienne B, Pérol M, Nesme P, Vuillermoz S, Robinet G, Guérin JC

[Acute diffuse interstitial pneumopathy following docetaxel (Taxotère). Apropos of 2 cases].

Revue des maladies respiratoires 1998 Apr;15;199-203 — 1998 Apr — 199-203

Merad M, Le Cesne A, Baldeyrou P, Mesurolle B, Le Chevalier T

Docetaxel and interstitial pulmonary injury.

Annals of oncology : official journal of the European Society for Medical Oncology 1997 Feb;8;191-4 — 1997 Feb — 191-4