The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Acute pulmonary edema after local infiltration of epinephrine during mastoidectomy: A case report.
Korean journal of anesthesiology 2009 Apr;56;462-465 — 2009 Apr — 462-465
Adrenaline induced pulmonary oedema.
Journal of anaesthesiology, clinical pharmacology 2011 Jan;27;132-3 — 2011 Jan — 132-3
Lessons for management of anaphylaxis from a study of fatal reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000 Aug;30;1144-50 — 2000 Aug — 1144-50
Delayed-onset epinephrine-induced pulmonary edema.
Anesthesiology 1999 Oct;91;1169-70 — 1999 Oct — 1169-70
Adrenaline-induced pulmonary oedema and its treatment. A report of two cases.
British journal of anaesthesia 1971 Jul;43;709-12 — 1971 Jul — 709-12
New developments in synthetic bone replacement materials.
Current opinion in dentistry 1992 Mar;2;97-103 — 1992 Mar — 97-103