The Drug-Induced Respiratory Disease Website

Anticoagulants, oral (vitamin K antagonists-VKA)

Hemomediastinum - Mediastinal hematoma

Abaskaron M, Peterson G, Huang TY

Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.

Postgraduate medical journal 1983 Feb;59;95-7 — 1983 Feb — 95-7

Packer JM

Radiologic seminar CXXI: hemomediastinum associated with anticoagulant therapy.

Journal of the Mississippi State Medical Association 1972 Oct;13;434-5 — 1972 Oct — 434-5

Huguenin A, Leborgne P, Pony JC, Lejwi G, Le Carrères D

[Unusual radiologic aspect of a mediastinal hematoma].

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 1968 Nov 08;44;2827-30 — 1968 Nov 08 — 2827-30

Di Pasquale G, Salpietro V, Boaron M

[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].

Giornale italiano di cardiologia 1990 Oct;20;972-5 — 1990 Oct — 972-5

Kaplinsky N, Deutsch V, Har Zahav V, Frankl O

[Mediastinal bleeding during anticoagulant simulating dissecting hematoma].

Harefuah 1978 Mar;94;172-3 — 1978 Mar — 172-3

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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