The Drug-Induced Respiratory Disease Website

Amphotericin B (infusion)

Path: Lipid/fat embolism

Specific staining may be required to separate exogenous/foreign lipids from fat and silicone (PMID 23020716)

Tolentino LF, Tsai SF, Witt MD, French SW

Fatal fat embolism following amphotericin B lipid complex injection.

Experimental and molecular pathology 2004 Dec;77;246-8 — 2004 Dec — 246-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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