The Drug-Induced Respiratory Disease Website

Statins

Acute fibrinous organizing pneumonia (AFOP)

Alghough not explicitely stated in these 2 papers, authors confirmed thir respective patient was on a statin

Publications

Tzouvelekis A, Koutsopoulos A, Oikonomou A, Froudarakis M, Zarogoulidis P, Steiropoulos P, Mikroulis D, Antoniades A, Bouros D

Acute fibrinous and organising pneumonia: a case report and review of the literature.

Journal of medical case reports 2009 Oct 12;3;74 — 2009 Oct 12 — 74

Bhatti S, Hakeem A, Torrealba J, McMahon JP, Meyer KC

Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure: successful treatment with mycophenolate mofetil and corticosteroids.

Respiratory medicine 2009 Nov;103;1764-7 — 2009 Nov — 1764-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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