The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Successful rechallenge with etoposide phosphate after an acute hypersensitivity reaction to etoposide.
Pharmacotherapy 1999 Aug;19;989-91 — 1999 Aug — 989-91
Hudson MM, Weinstein HJ, Donaldson SS, Greenwald C, Kun L, Tarbell NJ, Humphrey WA, Rupp C, Marina NM, Wilimas J
Acute hypersensitivity reactions to etoposide in a VEPA regimen for Hodgkin's disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993 Jun;11;1080-4 — 1993 Jun — 1080-4
Hypersensitivity reactions induced by etoposide.
Cancer treatment reports 1984 Jul-Aug;68;959-61 — 1984 Jul-Aug — 959-61