Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XI.a

Pulmonary arterial hypertension

May reverse with drug discontinuation. Generally similar to primary PHTn clinically, hemodynamically and on pathology. PMID 23997051. A few cases are thromboembolic in nature (PMID 24881082). Reviews at PMID 29508628, 30545968

Publications

Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.

American journal of respiratory and critical care medicine 2012 Oct 15;186;790-6 — 2012 Oct 15 — 790-6

Natali D, Girerd B, Montani D, Soubrier F, Simonneau G, Humbert M, Sitbon O

Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.

Chest 2011 Oct;140;1066-1068 — 2011 Oct — 1066-1068

Souza R, Humbert M, Sztrymf B, Jaïs X, Yaïci A, Le Pavec J, Parent F, Hervé P, Soubrier F, Sitbon O, Simonneau G

Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases.

The European respiratory journal 2008 Feb;31;343-8 — 2008 Feb — 343-8

Goldstein SE, Levy Y, Shoenfeld Y

[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].

Harefuah 1998 Dec 01;135;489-92, 568 — 1998 Dec 01 — 489-92, 568

Rich S, Rubin L, Walker AM, Schneeweiss S, Abenhaim L

Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.

Chest 2000 Mar;117;870-4 — 2000 Mar — 870-4

Rothman RB, Ayestas MA, Dersch CM, Baumann MH

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.

Circulation 1999 Aug 24;100;869-75 — 1999 Aug 24 — 869-75

Louis WJ

Primary pulmonary hypertension and anorectic drugs.

The New England journal of medicine 1999 Feb 11;340;480-2 — 1999 Feb 11 — 480-2

Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Hervé P

Primary pulmonary hypertension associated with the use of fenfluramine derivatives.

Chest 1998 Sep;114;195S-199S — 1998 Sep — 195S-199S

Delcroix M, Kurz X, Walckiers D, Demedts M, Naeije R

High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.

The European respiratory journal 1998 Aug;12;271-6 — 1998 Aug — 271-6

Kramer MS, Lane DA

Aminorex, dexfenfluramine, and primary pulmonary hypertension.

Journal of clinical epidemiology 1998 Apr;51;361-4 — 1998 Apr — 361-4

Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Bégaud B

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.

The New England journal of medicine 1996 Aug 29;335;609-16 — 1996 Aug 29 — 609-16