The Drug-Induced Respiratory Disease Website

Amiodarone

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

(Fr: fibrose pulmonaire accélérée). Often refractory to costicosteroid therapy. Can be fatal. See also under Iy

Newmarch W, Puopolo A, Weiler M, Casserly B

Hamman-Rich syndrome: a forgotten entity.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2017 05 18;87;799 — 2017 05 18 — 799

Kharabsheh S, Abendroth CS, Kozak M

Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone.

The American journal of cardiology 2002 Apr 01;89;896-8 — 2002 Apr 01 — 896-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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