Philippe Camus, M.D.

Dijon, France

Back to drug

The Drug-Induced Respiratory Disease Website

XII.b

Pericardial effusion (w/wo tamponade)

Pericarditis (i.e. pericardial inflammation) is usually heralded by acute mediothoracic chest pain (PMID 10878205). Large effusions can be ANA positive and cause pericardial tamponade. When present as a longterm sequela, pericardial thickening may cause restriction and constriction. See also under Vc, d, g, m and XIIk (PMID 20511488, 23376916)

Publications

Meng L, Deng B, Liu B, Gordon D

Association of sirolimus with pericardial effusion in renal transplant patient and discussion of potential mechanism.

BMJ case reports 2019 Jul 15;12; — 2019 Jul 15

Joo SJ, Yildirim I, Stenger EO, Anderson EJ

Sirolimus-associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient.

Pediatric transplantation 2019 Jun;23;e13425 — 2019 Jun — e13425

Bertrand D, Desbuissons G, Pallet N, Debure A, Sartorius A, Anglicheau D, Mamzer MF, Legendre C, Sberro-Soussan R

Sirolimus therapy may cause cardiac tamponade.

Transplant international : official journal of the European Society for Organ Transplantation 2013 Feb;26;e4-7 — 2013 Feb — e4-7