The Drug-Induced Respiratory Disease Website
Hypersensitivity and infusion reactions. May mimic systemic vasculitis (PMID 30746133). See also under 'Anaphylaxis' (Xf). Hypersensitivity reactions include the rapid development of malaise, cough, dyspnea, wheezing-bronchospasm, cutaneous rash, itching and pruritus. These symptoms may annunciate the onset of anaphylaxis (see Xf) especially if the drug is continued or the patient is inadvertenly rechallenged with the drug. Desensitization can be offered (PMID 26895621), so that patients can receive full treatment courses and need not be switched to an alternative, potentially more toxic or inferior therapy. See PMID 12634903, 12721396, 22149339, 22987983. Skin manifestations at PMID 24820798
Publications
Coping with toxicities of docetaxel (Taxotere).
Annals of oncology : official journal of the European Society for Medical Oncology 1993 Aug;4;610-1 — 1993 Aug — 610-1
Docetaxel (Taxotere) in advanced malignant melanoma: a phase II study of the EORTC Early Clinical Trials Group.
European journal of cancer (Oxford, England : 1990) 1994;30A;1061-4 — 1994 — 1061-4