The Drug-Induced Respiratory Disease Website

Chemicals

Reactive airway dysfunction syndrome (RADS)

(Fr: Sd de dysfonction des voies aériennes)

Saboo K, Gemnani RR, Sharma S, Kumar S, Acharya S

Chemical Pneumonitis and Reactive Airways Dysfunction Syndrome After Fumigation Exposure to Dimethanol and Glutaraldehyde: A Silent Menace Unmasked.

Cureus 2023 Aug;15;e42939 — 2023 Aug — e42939

Fong I, Chew SY, Tan KL

A 27-Year-Old Man With Persistent Breathlessness After an Inhalational Injury.

Chest 2021 Apr;159;e197-e201 — 2021 Apr — e197-e201

Bhardwaj R, Ducatman A, Finkel MS, Petsonk E, Hunt J, Beto RJ

Chronic pulmonary dysfunction following acute inhalation of butyl acrylate.

The West Virginia medical journal 2012 Nov-Dec;108;28-32 — 2012 Nov-Dec — 28-32

Khalid I, Godfrey AM, Ouellette DR

Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report.

Journal of medical case reports 2009 Nov 09;3;112 — 2009 Nov 09 — 112

Murphy DM, Fairman RP, Lapp NL, Morgan WK

Severe airway disease due to inhalation of fumes from cleansing agents.

Chest 1976 Mar;69;372-6 — 1976 Mar — 372-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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